I doubt the setting: Skip ADIRS Alignment, or Always show Sidestick position would screw up FGFS
So do I, but it's a matter of habit and setting a consistent design example.
See, I live in a rural area where traffic density is low. I doubt anything bad is going to happen if I do not look left and right before driving onto the 'main' road. Yet - that's still no good reason to do it. It's bad to acquire the habit of skipping the check, and it's even worse to set a bad example to others.
So let me ask you the other way - how do you know what settings are harmless to save that way? Can you be sure they all behave like you expect on other systems? I can offhand list a dozen examples where something worked perfectly fine for me and I never thought anything evil till it really malfunctioned for someone else - because he was using FG differently, or the graphics driver was different,... With time, there comes a certain humility in gauging one's potential to wreck havoc for others.
Anyway - please take it as a well-meant bit of advice from two people who have their share of experience in making bad mistakes - it's not a good idea.