Are you certain you are not experiencing power or heat problems with your computer? One of the symptoms of power sags is USB problems.
I would be having problems right now if I wasn't aware of this.
I removed my wimpy 240w power supply and replaced it with a 600w CoolerMaster supply.
I replaced the case fans with Noctua fans.
My challenge would be the 75 watts used/radiated from my GTX1050Ti video card.
Edit: If the problem occurs intermittently, and mainly when you are flying IFR and on approach, I would suspect heat or power. My computer really struggles to keep up. I drop to about 30fps from 60.